|
KMID : 0043319860090030139
|
|
Archives of Pharmacal Research
1986 Volume.9 No. 3 p.139 ~ p.144
|
|
|
Fluorescence Probe Study on the Solubilization Sites of Aniline Derivatives in Triton X-100 and Zephiramine Micelles
|
|
Han SK
Lee YS
|
|
|
Abstract
|
|
|
|
The solubilization sites of aniline and its derivatives in micelles were investigated with fluorescence probe technique. The fluorescence probes employed in this study are 12-(9-anthroyl) stearic acid (AS) and 2-p-toluidinylnaphthalene-6-sulfonate (TNS) which are incorporated in the interior of the micelle and attached to its surface, respectively. As these two probes were effectively quenched by aniline and its derivatives, the modified Stern-Volmer relationship in micellar system could be applicable to estimate the partition coefficient, KP of the solubilizate between aqueous and micellar phase. Because KP derived by this method reflects the relative proximity of the fluorophore to the quencher, the ratio of KP in the surface area to that in the interior of the micelle is interpreted in terms of the relative location of the solubilizate in micellar aggregate. The results show that the solubilizates are not located in a definite position but distributed in the multiple-sites of the micelle. The solubilization sites of the solubilizates in the micelle are dependent on their structures. As the solubilizate has more numbers of N-substituents of aniline and more numbers of carbon in the substituent, it tends to incorporate in the interior of the micelle more effectively.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|